Molecular basis of anthracycline- induced cardiotoxicity
نویسندگان
چکیده
Anthracyclines are highly effective chemotherapeutic agents used to treat a wide variety of malignancies. Cardiotoxicity is a well recognized side effect of anthracycline therapy that limits the total amount of drug administered and can cause heart failure in some patients. Most experimental data support oxidative stress as the etiology of anthracycline-induced cardiotoxicity. This review will discuss the effect of anthracycline cardiotoxicity on human hearts and present insight into the cellular and subcellular mechanisms believed to be responsible for the lethal myocyte injury associated with anthracycline cardiotoxicity. Heart Metab. 2007;35:1–4.
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